Computational genomicist at University of Copenhagen, Section for Computational and RNA Biology.

The Andersson lab focuses on genomics and computational/statistical modelling of transcriptional regulation based on large-scale sequencing data. Our main aims are to characterize and better understand the architectures of transcriptional regulation and the fundamental properties of enhancers and promoters.

My major accomplishments during my postdoc (Albin Sandelin lab) are work done with the FANTOM consortium, in which I have used human transcription initiation sites to produce an unprecedented atlas of active enhancers across the vast majority of human cell types and tissues (DOI:10.1038/nature12787). The atlas was used to compare regulatory programs between different cells at unprecedented depth, to identify disease-associated regulatory single nucleotide polymorphisms, and to classify cell-type-specific enhancers.

Previous defining work includes:

• characterization of a chromatin state for exons (DOI:10.1101/gr.092353.109);
• profiling of DNA copy number variations (CNVs) and aberrations (DOI:10.1002/humu.20659); and
• identification of somatic mosaicism for CNVs in differentiated tissues (DOI:10.1002/humu.20815) and between monozygotic twins (DOI:10.1016/j.ajhg.2007.12.011)