Regina Wallace-Jones assumed the role of President and CEO of ActBlue in January 2023, leading the nonprofit organization that serves as the Democratic Party's primary fundraising infrastructure. Since its 2004 founding, ActBlue has raised more than $18 billion for Democratic candidates and progressive causes. She became the first Black woman to serve as chief executive in the organization's history. During the 2023–2024 election cycle, ActBlue processed $3.8 billion in contributions under her leadership.

Her professional background uniquely combines technical training with policy expertise. Born in West Covina, California, to union laborer parents Edward and Alice Wallace, she earned a Bachelor of Science in Electrical Engineering from Stanford University, where she was initiated into Delta Sigma Theta sorority. She obtained a Master of Public Policy from UCLA Luskin School of Public Affairs in 1999, concentrating on telecommunications and technology policy.

Wallace-Jones accumulated more than 25 years of technology leadership experience. She began as a systems engineer at Motorola before progressing through multiple positions at Covad Communications, advancing to Director of Operations. At Yahoo, she served as Senior Director of Technology & Operations. At Facebook, she held the position of Chief of Staff and Head of Security Operations. At eBay, she served as Chief of Staff and Head of Product Operations. Her progression at Mindbody included SVP of Product Services, SVP of Insight & Innovation, and SVP of Products & Engineering, where she led teams across four continents with responsibility for $50 million in annual revenue. She served as Chief Operating Officer at LendStreet, a financial technology company focused on debt restructuring.

Her political engagement began during President Obama's 2012 re-election campaign, when she served as Regional Field Organizer for Organizing for America in California, coordinating grassroots volunteers while working at Yahoo and caring for young daughters. She won election to the East Palo Alto City Council in November 2018 with 2,370 votes, placing first among seven candidates and defeating a 13-year incumbent. Her colleagues voted to appoint her Vice Mayor immediately upon taking office and later selected her as Mayor in 2020. During her mayoral tenure, she led the city through the COVID-19 pandemic, establishing widespread testing sites when East Palo Alto's positivity rate reached 15.4 percent — more than three times the county's 4.1 percent rate.

She serves as a mentor with StreetCode Academy, a nonprofit providing free technology education to underserved communities in Silicon Valley, and chairs the board of Sama, a B Corp certified AI company. UCLA Luskin School of Public Affairs named her 2023 MPP Alumna of the Year. U.S. Representative Jackie Speier entered a Congressional Record statement recognizing her East Palo Alto service.