Janani Ravi

I am a computational biologist working on host-pathogen biology, protein sequence-structure-function relationships, and drug repurposing. I am interested in quantitative biology across the board, like to code & develop methods, and enjoy being in a collaborative environment doing problem-solving while addressing interesting biological questions.

I also like teaching statistical data analysis and visualization, and R/Python programming.

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During my postdoctoral research at Rutgers University, I focused on using computational approaches to study various facets of host and pathogen biology including:

i) delineating the molecular mechanism underlying a newly identified stress response operon in the tubercle bacterium involving the phage-shock-proteins (psp);

ii) unraveling the evolution of bacterial stress response systems (psp) across the tree of life using protein sequence-structure-function relationships;

iii) reconstructing and analyzing the mycobacterial sigma factor regulatory network;

iv) characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis;

v) understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations.

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I graduated from Virginia Tech with a Ph.D. in Genetics, Bioinformatics and Computational Biology. During my graduate research, I worked on modeling a critical checkpoint in the budding yeast cell cycle, and the dynamics of the Wnt pathway.

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I completed my undergraduate degree (B.Tech) at Anna University, Chennai, India majoring in Biotechnology.