Born in Heraklion, Crete, Greece, Konstantinos Papadakis has performed in recitals and has collaborated with chamber ensembles and orchestras in the world's major concert halls and famous artistic centers, such as Wigmore Hall, Jordan Hall, the Athens Megaron Concert Hall, New York's Carnegie Hall and St. Petersburg's Grand Concert Hall, where he performed the world premieres of works by Greek and Russian contemporary composers. The Boston Globe says of his playing: "Papadakis gave a stunning performance displaying great variety of attack, poetic lyricism, and wrists of carbon steel."

In 2006 Papadakis was appointed the Samuel Barber Artist in Residence at West Chester University in West Chester, Pennsylvania, where he remained until 2011. In September 2011, Konstantinos joined the faculty of the New England Conservatory's Pre-College and Continuing Education Divisions.