Marco Emanuele Favretto

Nijmegen Centre for Molecular Life Sciences

Marco Emanuele Favretto

Nijmegen Centre for Molecular Life Sciences

Currently, I am working as a postdoc with expertise in drug delivery in the group of Prof. Roland Brock at the Department of Biochemistry, NCMLS, Radboud University Nijmegen Medical Centre, The Netherlands.

I am working mainly on two fields of research: strategies for polymer-based drug delivery systems and the use of human red blood cells as drug vehicles. In particular, I have been developing a workflow for high-throughput screening of splice-correcting polyplexes which incorporate biologically relevant functionalities. I have also been developing loading strategies to encapsulate therapeutics into erythrocytes and predict their in vivo behavior as drug delivery systems.

During my PhD at the University of Kent, I worked on targeted arsonoliposome delivery to the brain for the treatment of brain tumours. The project was focusing on the evaluation of the arsonoliposome-selective toxicity towards cancer cells, the uptake mechanisms by either tumour or hCMEC cell lines and the enhancement of blood brain barrier permeability to antibody-functionalized arsonoliposomes. Other projects in which liposome technology was involved included the development of targeted porphyrin formulations for photodynamic therapy and the incorporation of artemisinin derivatives for cancer therapy.

I have worked on additional projects in the field of nanotechnology, such as the assessment of the pharmacological profile of self-emulsifying drug delivery systems and fullerene-based drugs. I have developed a synthetic strategy to produce functionalized quantum dots with high fluorescence yield and loading procedure to incorporate poorly soluble drugs into silica nanoparticles.

  • Work
    • Post Doc at NCMLS
  • Education
    • PhD in Pharmacy, University of Kent